Matthew J. Silva email: silvam@wustl.edu Yalem Building, 8th Floor Phone: +1 (314) 362-8585 FAX: +1 (314) 362-0334 Departments of Orthopaedic Surgery and Biomedical Engineering Washington University Campus Box 8233 St. Louis, MO 63130

  Matthew J. Silva
  Associate Professor of Orthopaedic Surgery and Biomedical Engineering (Joined 1996)

• Ph.D., Mechanical Engineering, MIT, 1996
• M.Eng., Mechanical Engineering, Cornell, 1984
• B.S., Mechanical Engineering, Cornell 1982

 Research Interests:

• Mechanobiology of Bone
  
  • Response of the osteoporotic skeleton to in vivo loading
  • Osteogenic and angiogenic response to skeletal fatigue loading
  • Mechanical properties of bone - effects of altered genetics or metabolism
  
  
  
• Tendon and ligament injury and repair
  
  • Histological and biomechanical characteristics of healing tendon-bone junction
  
  

 Post-Doctoral and Graduate Research Associates:

• Gregory Wohl, Ph.D.
• Manolis Zampiakis, M.D.
• Blaine Christiansen
• Jenny Lynch
• Brian Uthgenannt

 Staff:

• Michael Brodt, M.S., Lab Manager
• Melissa Zaegel, Research Engineer
• Michelle Lynch, Research Technician
• Tim Morris, Sr. Research Technician

  Representative Publications:

• Christiansen BA, Silva MJ. " The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice. "   Ann Biomed Eng. 34(7):1149-56, 2006.
• Silva MJ, Uthgenannt BA, Rutlin JR, Wohl GR, Lewis JS, Welch MJ. " In Vivo Skeletal Imaging of 18F-Fluoride with Positron Emission Tomography Reveals Damage- and Time-Dependent Responses to Fatigue Loading in the Rat Ulna. "   Bone 39(2):229-36, 2006.
• 66. Uthgenannt BA, Silva MJ. " Use of the Rat Forelimb Compression Model to Create Discrete Levels of Bone Damage In Vivo. "   J Biomech. 2006 Mar 4; [Epub ahead of print]
• Silva MJ, Thomopoulos S, Kusano N, Zaegel MA, Harwood FL, Matsuzaki H, Havlioglu N, Dovan TT, Amiel D, Gelberman R. " Flexor tendon to bone healing: mechanical, histological and densitometric evidence of poor tendon healing after repair in a bone tunnel. "   J. Orthop. Res. 24(5): 990-1000, 2006.
• Silva MJ, Brodt MD, Wopenka B, Thomopoulos S, Williams DE, Wassen MH, Ko M, Kusano N, Bank RA. " Decreased collagen organization and content are associated with reduced material strength of demineralized and intact bone in the SAMP6 mouse. "   J Bone Miner Res. 21: 78-88, 2006.
• Silva MJ, Brodt MD, Hucker WJ. " Finite element analysis of the mouse tibia: estimating endocortical strain during three-point bending in SAMP6 osteoporotic mice. "   Anat Rec A Discov Mol Cell Evol Biol. 2005 Apr;283(2):380-90.

 Departmental Web Page: http://www.wuorthopaedics.com/